Solid Snake / Solidus Snake (voice)

Hal 'Otacon' Emmerich (voice)

Roy Campbell (voice)

Ocelot (voice)

Cyborg Ninja (voice)

Liquid Snake (voice)

Emma Emmerich (voice)

Rosemary (voice)

Peter Stillman (voice)

Vamp (voice)

Raiden (voice)

Fortune (voice)

Fatman (voice)

Sergei Gurlukovich (voice)

Scott Dolph (voice)

Olga Gurlukovich (voice)

The Sorrow (voice)

President Johnson (voice)

Karen Hojo (voice)

Others (voice)

Others (voice)