Osmosis Jones (voice)

Drix (voice)

Mayor Paul Spryman / Hector's Mom (voice)

Hector Cruz (voice)

Maria Amino (voice)

Police Chief Gluteus (voice)

Travis Lum (voice)

Ellen Patella (voice)

Pnuemoniac (voice)

Dander (voice)

The Mole (voice)

Abglobtus Goop (voice)

Christine Kolchuck (voice)

Rescue Cell (voice)

Mayor Santorini (voice)

Nick O'Teen (voice)

Ashley / Carbon Monoxide (voice)

Strepfinger (voice)

Cilia Tyson (voice)

Hector's Dad (voice)

Captain Quinine (voice)